Supply and Installation of PhysioMimix OOC Multi-OrganFull System

The PhysioMimix® Multi-Tissue System offers a highly advanced, solution for modelling systemic human biology in vitro. By enabling the dynamic co-culture of multiple organ models-such as liver, gut, and lung-within a single, perfused microphysiological system, it provides a unique opportunity to assess inter-organ interactions, drug metabolism, distribution, and toxicity in a more integrated and human-relevant context. Product features include an open-well consumable plate design, media is pneumatically pumped recirculated through microfluidics within these plates to perfuse tissue cultures. Modular PhysioMimix® hardware consists of a Controller, Docking Station(s), and MPS driver(s), and consumable plates controlled via proprietary software. This is underpinned by patents exclusively licensed from MIT to CN Bio.

This system is particularly valuable for studying drug pharmacokinetics and pharmacodynamics (PK/PD) across tissues, evaluating how metabolites formed in one organ (e.g., liver) influence the function or toxicity of others. Such capability is crucial for understanding off-target effects, bioactivation pathways, and multi-organ toxicity that are often missed in single-organ or animal models.